The chamomiles (or camomiles) have long been used and cultivated by Europeans and Americans. There is hardly one western herbal published in the past 500 years that does not include this group of plants. Tyler (1993) notes that the Germans refer to it as alles zutraut (capable
of anything), equating its reputation (though not uses) as a popular
European herb with the status afforded ginseng in other cultures.
Nomenclature
The word chamomile is derived from the Greek chamos (ground) and melos (apple), referring to the plant's low growing habit and the fact that the fresh blooms are somewhat apple-scented (Smith, 1963).
According
to Hill (1948), accurate identity of a plant under discussion as
"chamomile" is hampered by the fact that the name has been applied to a
dozen or more species in six genera of the aster family (Asteraceae or
Compositae). However, of all these plants, only two species are
generally utilized in the herb trade and in broad historical folk usage.
Unfortunately
for the botanist and lay person alike, both of those species have, in
the past 20 years, been referred to by as many as five different Latin
species names, as well as a number of common names. Tucker (1986; Tucker
et al., 1987, 1989) retains Chamomilla recutita (L.)
Rauschert as the proper botanical name of the "common chamomile" of the
European continent, better known as Hungarian or German chamomile, also
known by the synonyms Matricaria chamomilla and M. recutita. Tucker and co-workers cite Kay et al. (1976) as the authority. However, Jeffery (1979) provides convincing evidence for relegating the genus name Chamomilla to synonymy with Matricaria. Conveniently, Matricaria recutita is the name cited in Hortus Third (Liberty
Hyde Bailey Hortorium,- 1976). This book has been widely used as a
source of botanical names by the American herb trade. The unfortunate
part of this taxonomic shuffling is that the lay person, herb trader, or
research scientist must source information on the plant under at least
three different Latin names, depending upon the year of publication.
Such a complex problem for a simple herb! Henceforth, we will deem the
major source plant of the chamomile of commerce Matricaria recutital "German chamomile," at least until a taxonomist provides a more definitive interpretation of the nomenclature.
Let's
turn to the "common chamomile" of England, better known as English or
Roman chamomile. In many herb books published prior to 1976, this plant
is called Anthemis nobilis L. However, in 1785, an Italian botanist, Carlo Allioni (1728-1804), placed this plant in the genus Chamaemelum, naming it Chamaemelum nobile (L.) All. Buried in obscurity for nearly 200 years, the name resurfaced in the mid-1970s and was adopted in volume 4 of Flora Europaea, as well as Hortus Third. It is again retained by Tucker (1986; Tucker etal., 1987,1989). Chamaemelum nobile is best
known as Roman chamomile, the name by which we will refer to it here.
The name Roman chamomile was first bestowed upon the plant by Joachim
Camerarius in 1598, after observing it growing abundantly in the
vicinity of Rome (Fluckiger and Hanbury, 1879).
History
German
chamomile is a sweet-scented, smooth, branched annual growing to 2 1/2
ft. in height. It is native to Europe and Western Asia, and has become
widely naturalized in the U.S. (L. H. Bailey Hortorium, 1976).
Roman
chamomile is an aromatic, creeping perennial, growing to one foot in
height. It hails from the United Kingdom (UK) and is widely grown in
American herb gardens.
Historically,
Roman and German chamomiles have been used interchangeably or confused.
The German is preferred on the European continent, while the Roman
chamomile has been more widely used in the U.K. In the U.S., German
chamomile is by far the most widely consumed of the two species. Despite
the fact that the two plants have often been lumped together as
"chamomiles," their chemical components and essential oils are quite
different, and each should be treated as a separate entity (Mann and
Staba, 1986). In addition to genetic differences, quality and quantity
of essential oil and other plant components, as in most medicinal
plants, are dependent upon a wide range of variables such as
environmental factors, cultivation practices, plant part, plant age, and
postharvest handling. Articles relative to these subjects are cited by
Mann and Staba, (1986) and Simon, Chadwick, and Craker (1984).
German
chamomile has a long tradition as a folk or domestic remedy used for a
wide variety of purposes including an external compress or fomentation
for sciatica, gout, lumbago, inflammations, rheumatism, and skin
ailments. A tea (infusion), decoction, or tincture has long been used
for treating colic, convulsions, croup, diarrhea, fever, indigestion,
insomnia, infantile convulsions, toothache, bleeding or swollen gums, a
folk cancer remedy, and many other uses. Historically, Roman chamomile
has been utilized for similar purposes. It is best known as a
pleasant-tasting, or healthful beverage tea (Leung & Foster, 1996;
Duke, 1985).
Safety
In
the late 1970s and the 1980s several popular and scientific articles
strongly warned against drinking chamomile tea, the warning based on an
isolated report of anaphylactic reaction resulting from drinking
chamomile tea (Casterline, 1980; Benner and Lee, 1973). One report
(Hausen, 1979) tested 25 human subjects known or thought to be allergic
to aster family members, and found that two of the patients (8 percent)
were allergic to chamomile. Cross-reactions with other aster family
members were also observed.
Mann
and Staba (1986) suggest that a possible source of allergic reactions
attributed to chamomile flowers may be other closely related, more
allergenic plants, such as Anthemis cotula, dog fennel or
mayweed, which is known to cause toxic or irritating reactions, and is
sometimes offered as or may be an adulterant to chamomile. These authors
suggest proper identification and purity of chamomiles as a
preventative measure, but warn that those with known sensitivities to
aster family members (including ragweed, asters, chrysanthemums, etc.)
may best be advised to avoid German and Roman chamomiles and their
products.
In
the proposed European monograph on chamomile flowers produced by ESCOP
(European Scientific Cooperative for Phytotherapy) there are several
headings that address issues relative to potential side effects or
adverse reactions. These include headings for contraindications, side
effects, use during pregnancy and lactation, special warnings,
interactions, duration of administration, and overdose. Under
contraindications, we find "none known." Use during pregnancy and
lactation? "No adverse effects reported." Special warnings? "None
required." Interactions? "None reported." Duration of administration?
"No restriction." Overdose? "No intoxication symptoms reported." The
side effect heading in the ESCOP monograph reads, "Extremely rare
contact allergy" (ESCOP, 1990). What is rare? Tyler (1993), while
reiterating a word of caution for those who suffer from hypersensitivity
to ragweeds and other aster family members, notes that normal persons
should not be deterred from consuming the herb. He cites a survey of
world literature (Hausen, Busker, and Carle, 1984) which found only
about 50 reports of chamomile allergies reported between 1887 and 1982.
Only five of these reports were attributed to the widely available
German chamomile (Matricaria recutita). The vast majority involved the genus Anthemis, primarily Anthemis cotula, which
is not in commerce. These reports, however, emphasized the need for
proper identification of source plants used in herbal preparations. The
Commission E, an expert panel of the German Institute for Drugs and
Medical Devices, concurs that there is no known adverse reactions nor
contraindications for the nonprescription drug use of German chamomile
(Blumenthal, et al., 1996).
Contemporary Medicinal Use
Azulenes,
a group of chemical components found in both species of chamomile,
possess experimental antiallergenic activity (Farnsworth and Morgan,
1972; Mann and Staba, 1986). Both histamine release and inhibition of
histamine discharge have been advanced as mechanisms for the potential
antiallergenic action of azulenes. Mann and Staba (1986) suggest that,
since azulenes seem to prevent allergenic seizure, inhibition of
histamine is probably involved in the true mechanism of their action.
In
modem Europe, chamomile products, including extracts, tinctures,
tisanes (teas), and salves, are widely used as anti-inflammatory,
antibacterial, antispasmodic, and sedative agents. Extracts are used to
allay pain and irritation, clean wounds and ulcers, and aid prevention
and therapy of irradiated skin injuries, as well as treat cystitis and
dental afflictions (Mann and Staba, 1986). The plant is included in the
pharmacopeias of 26 countries (Salamon, 1992).
The
German Commission E approves German chamomile preparations for external
use in cases of inflammations of skin and mucous membranes, bacterial
skin diseases, diseases of mouth and gums, inflammation and irritation
of the upper respiratory tract, and inflammations of the ano-genital
area by using chamomile baths. Internally, chamomile is approved for
gastrointestinal spasms and inflammatory diseases of the
gastrointestinal tract. The flowers must have a minimum of four percent
essential oil (Blumenthal, et al., 1996).
Extracts
and a number of components of chamomile, including azulenes
(chamazulene) and alpha-bisabolol, have been shown to have
anti-inflammatory activity. Chamazulene, comprising 5 percent of the
essential oil, is an artifactual component formed during heating of teas
and extracts (Der Marderosian and Liberti, 1988). This activity has
been demonstrated, not only by long empirical use, but by a number of
different laboratory models as well. Studies also show that
alpha-bisabolol has a protective effect against peptic ulcers, as well
as antibacterial and antifungal activity. Alpha-bisabolol has also been
shown to reduce fever and shorten the healing time of skin burns in
laboratory animals (Der Marderosian and Liberti, 1988). These two
compounds are considered primary active components in German chamomile.
Many commercial German chamomile preparations are standardized to
chamazulene and alpha-bisabolol content (Tyler, 1993; Mann and Staba,
1986).
Four basic chemical types of Matricaria recutita (A,
B, C, and D) are now recognized according to qualitative and
quantitative analysis of the essential oil. Consequently, in the major
chamomile production countries (Argentina, Czech Republic, Germany,
Hungary, Poland, and Slovakia), intensive plant improvement programs
have been initiated to produce plants with high levels of defined
chemical components (Salamon, 1992).
About
120 secondary metabolite chemical constituents have been identified in
chamomile, including 28 terpenoids, 36 flavonoids, and 52 additional
compounds, all with potential pharmacological activity (Salamon, 1992).
Components in the essential oil of German chamomile contribute to its
smooth muscle relaxing activity. Nonvolatile constituents, including
flavones (apigenin, luteolin, patuletin, and quercetin) are also
antispasmodic (Tyler, 1993). Chamomile teas absorb only about 10-15
percent of the essential oil available in the flowers, but, if used over
a long period of time, have the potential for a cumulative therapeutic
effect (Der Marderosian and Liberti, 1988; Farnsworth and Morgan, 1972).
Summary
Chamomiles
have been used for centuries in teas as a mild, relaxing sleep aid,
treatment for fevers, colds, stomach ailments, and as an
anti-inflammatory, to name only a few therapeutic uses. Extensive
scientific research over the past 20 years has confirmed many of the
traditional uses for the plant and established pharmacological
mechanisms for the plant's therapeutic activity, including antipeptic,
antispasmodic, antipyretic, antibacterial, antifungal, and
antiallergenic activity. In addition to medicinal use, chamomiles enjoy
wide usage, especially in Europe, Latin America, and the U.S., as a
refreshing beverage tea and as an ingredient in numerous cosmetic and
external preparations. One source estimates that over one million cups
of chamomile tea are ingested worldwide each day (McCaleb, 1990).
Reference Source: Herbal gram.org
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